Curriculum I. Saggio

Appointments

2010

Visiting scientist Pasteur Institute Paris France

2009

Visiting scientist Salk Institute La Jolla CA Usa

2004-to date

Associate Professor Genetics and Gene Therapy and group leader, Department of Genetics and Molecular Biology University of Rome La Sapienza.

Group Leader, Institute of Cell Biology and Tissue Engineering, San Raffaele Biomedical Science Park of Rome.

Associate scientist, Institute of Cell and Molecular Biology, C.N.R..

Director, Master in Life science communication, Department of Genetics and Molecular Biology University of Rome La Sapienza.

Italian coordinator, International Master in Genetics, Erasmus University la Sapienza/University of Paris 7.

2004

Visiting scientist Universite’ de Lyon France

1996-2003

Assistant Professor, Department of Genetics and Molecular Biology University of Rome La Sapienza.

1995-1996

 UE postdoctoral fellow, Laboratoire des Virus Oncogenes IGR, Paris.

1991-1994

PhD fellow Department of Genetics and Molecular Biology University of Rome La Sapienza / Department of Genetics IRBM P. Angeletti/ Merck laboratories.

1989-1990

Researcher, Laboratory of Virology Istituto Superiore di Sanita’.

1988

Laurea cum laude, Department of Genetics and Molecular Biology University of Rome La Sapienza.

Areas of interests

Virus-cell interactions and virus-mediated gene transfer.

Publications 2004-2009

Piersanti P, Remoli C, Saggio I, Funari A, Michienzi S, Sacchetti B, Gehron Robey P, Riminucci M and Bianco P. Transfer, analysis and reversion of the fibrous dysplasia cellular phenotype in human skeletal progenitors. J Bone Miner Res, in press

Caruso P, Burla R, Piersanti S, Cherubini G, Remoli C, Martina Y, Saggio I. Prion expression is activated by Adenovirus 5 infection and affects the adenoviral cycle in human cells. Virology. 2009 385(2):343-50

Martina Y, Avitabile D, Piersanti S, Cherubini G, Saggio I. Different modulation of cellular transcription by Adenovirus 5, E1E3- and fully deleted adenoviral vectors. Virus Research, 2007 Dec;130(1-2):71-84.

Sacchetti B, Funari A, Michienzi S, Di Cesare S, Piersanti S, Saggio I,Tagliafico E, Ferrari S, Robey P, Riminucci M, Bianco P. Self-renewing osteoprogenitors in bone marrow sinusoids are the organizers of the hematopoietic microenvironment. Cell, 2007 Oct 19;131(2):324-36..

Benihoud K, Esselin S, Descamps B, Julienne B, Salone B, Bobe P, Bonardelle E, Connault E, Opolon P, Saggio I, Perricaudet M. Respective roles of TNF-alpha and IL-6 in the immune response-elicited by Adenovirus-mediated gene transfer in mice. Gene Therapy. 2007 March 14; 6: 533-544.

Riminucci M, Saggio I, Robey P, Bianco P. Fibrous Dysplasia as a stem cell disease. J of Bone and Mineral Resarch. 2006 Dec 21 Suppl 2: 125-31.

Cherubini G, Petouchoff T, Grossi M, Piersanti S, Cundari E, Saggio I. Adenovirus (ONYX-015) Overrides G(1)/S and G(2)/M Checkpoints and Causes Mitotic Catastrophe and Endoreduplication in p53-Proficient Normal Cells. Cell Cycle. 2006 Oct 1;5(19)

Piersanti S, Sacchetti B, Funari A, Di Cesare S, Bonci D, Cherubini G, Peschle C, Riminucci M, Bianco P, Saggio I. Lentiviral transduction of human postnatal skeletal (stromal, mesenchymal) stem cells: in vivo transplantation and gene silencing. Calcif Tissue Int. 2006 Jun;78(6):372-84.

Campo S, Serlupi-Crescenzi O, Arseni B, Rossi S, Saggio I, Salone B, Cherubini G, Carminati P, De Santis R. Comparative activity of Sant7 and anti-IL-6, IL-6R monoclonal antibodies in a murine model of B-cell lymphoma. Cytokine. 2005 Sep 7;31(5):368-74.

Piersanti S, Martina Y, Cherubini G, Avitabile D, Saggio I. Use of DNA microarrays to monitor host response to virus and virus-derived gene therapy vectors. Am J Pharmacogenomics. 2004;4(6):345-56.

Piersanti S, Cherubini G, Martina Y, Salone B, Avitabile D, Grosso F, Cundari E, Di Zenzo G, Saggio I. Mammalian cell transduction and internalization properties of lambda phages displaying the full-length adenoviral penton base or its central domain. J Mol Med. 2004 Jul;82(7):467-76.

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